Enlarge figure ↗Published patent application · 2022
US20220379010A1
Research & publications
From models to published research.
My research focuses on cerebrospinal fluid dynamics, intrathecal drug delivery, patient-specific modeling, and propulsion.
Intellectual property
Patent applications & invention disclosures.
Four co-invented, published US patent applications. Drawings are extracted from the original application PDFs, with the publication and application numbers shown for each record.
Enlarge figure ↗
Enlarge figure ↗Published patent application · 2022
US20220370716A1
Fluid delivery systems and methods of treatment
Enlarge figure ↗Published patent application · 2022
US20220370710A1
Fluid delivery systems and methods of treatment
Enlarge figure ↗Published patent application · 2022
US20220143373A1
Systems, catheters, and methods for treating along the central nervous system
From research to invention
Submitted invention disclosures.
Titles and submission dates are recorded in my résumé. The images below come from related published research; public disclosure documents and record numbers are not available.
Enlarge figure ↗Submitted invention disclosure
Dual-lumen neurapheresis catheter for equal flow at aspiration and return ports.
Enlarge figure ↗Submitted invention disclosure
Subject-specific prediction and optimization of intrathecal (IT) drug therapy based on medical imaging and computational modeling.
Research impact
Citations & collaborators.
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Citations
453All time
344Since 2021
h-index
10All time
9Since 2021
i10-index
11All time
9Since 2021
Cited by year
Select a year to inspect its citation count. The current year is still in progress.
Open research
Public access
11Available
1Not available
Articles covered by funding mandates, as reported by Google Scholar.
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Selected figures come from the original PDFs. Open a figure to inspect it at full size, or follow the publisher, full-text, and Scholar links. Conference abstracts are listed separately.
14 journal articles
Peer-reviewed research.
Enlarge figure ↗2025 · Drug delivery
A 3D non-human primate digital model for pharmacokinetic prediction of intra-cerebrospinal fluid drug neuraxial dispersion
Fluids and Barriers of the CNS
Enlarge figure ↗2025 · Drug delivery
Computational and biological modeling of IGF1R inhibition for multifocal medulloblastoma
Communications Medicine
Enlarge figure ↗2025 · CSF dynamics
An In Vitro Platform for Pharmacokinetic Quantification and Optimization of Cerebrospinal Fluid Filtration and Drug Circulation
Journal of Medical Devices
Enlarge figure ↗2022 · Drug delivery
Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology
Fluids and Barriers of the CNS
Enlarge figure ↗2020 · CSF dynamics
Intrathecal catheter implantation decreases cerebrospinal fluid dynamics in cynomolgus monkeys
PLOS ONE
Enlarge figure ↗2020 · CSF dynamics
In vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to Neurapheresis therapy
Fluids and Barriers of the CNS
Enlarge figure ↗2020 · CSF dynamics
Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients
Fluids and Barriers of the CNS
Enlarge figure ↗2020 · CSF dynamics
Impact of Neurapheresis system on intrathecal cerebrospinal fluid dynamics: a computational fluid dynamics study
Journal of Biomechanical Engineering
Enlarge figure ↗2019 · CSF dynamics
Characterization of intrathecal cerebrospinal fluid geometry and dynamics in cynomolgus monkeys (macaca fascicularis) by magnetic resonance imaging
PLOS ONE
Enlarge figure ↗2018 · CSF dynamics
Anthropomorphic model of intrathecal cerebrospinal fluid dynamics within the spinal subarachnoid space: spinal cord nerve roots increase steady-streaming
Journal of Biomechanical Engineering
Enlarge figure ↗2017 · CSF dynamics
Nonuniform moving boundary method for computational fluid dynamics simulation of intrathecal cerebrospinal flow distribution in a cynomolgus monkey
Journal of Biomechanical Engineering
Enlarge figure ↗2017 · CSF dynamics
A 3D subject-specific model of the spinal subarachnoid space with anatomically realistic ventral and dorsal spinal cord nerve rootlets
Fluids and Barriers of the CNS
2017 · Propulsion
Three-dimensional simulation of a novel rotary-piston engine in the motoring mode
Propulsion and Power Research
2017 · Propulsion
Theoretical analysis of the conical premixed flame response to upstream velocity disturbances considering flame speed development effects
Propulsion and Power Research
Doctoral research
PhD dissertation.
Enlarge figure ↗2019 · Dissertation
Magnetic Resonance Image-based Numerical Modeling of Cerebrospinal Fluid Dynamics: Application to Filtration and Intrathecal Drug Delivery
University of Idaho · PhD dissertation
3 conference abstracts
Conference contributions.
2025 · Conference abstract
A novel approach for treatment of rett syndrome and other x-linked disorders through miREX gene regulation combined with FalconTM precision CSF delivery
Human Gene Therapy 36 (3–4), E280 · Conference abstract
2024 · Conference abstract
The miREX Platform Technology Allows for Highly Efficacious X-Reactivation for Treatment of X-linked Disorders
Molecular Therapy 32 (4), 317–318 · Conference abstract
2024 · Conference abstract
Leveraging In Silico and In Vitro Modeling for Optimization of Intrathecal AAV9 Delivery to the Brain: Validation in Nonhuman Primates and Translation to Human Rett Syndrome Patient Anatomy
Molecular Therapy 32 (4), 746–747 · Conference abstract
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